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| OEM | OEM Services Provided |
| Feature | Good stability |
| Classification | Paint Additives |
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Molecular Formula: C25H28N6O
Molecular Weight: 428.529
CAS No.: 138402-11-6
| Category | Details |
|---|---|
| Chemical Properties | Molecular formula: C25H28N6O<br> Molecular weight: 428.53 g/mol |
| Mechanism of Action | Irbesartan is an angiotensin II receptor antagonist (ARB) that selectively blocks the AT1 receptor, reducing the vasoconstrictive and aldosterone-secreting effects of angiotensin II, thereby lowering blood pressure. |
| Therapeutic Uses | Hypertension: Used alone or in combination with other antihypertensive agents to lower blood pressure.<br> Diabetic Nephropathy: Reduces proteinuria and protects kidney function in patients with type 2 diabetes and hypertension.<br> Heart Failure: Used as a second-line agent in the treatment of congestive heart failure. |
| Pharmacokinetics | Absorption: 60-80% bioavailable, with peak plasma concentrations reached in 1.5-2 hours.<br> Distribution: Volume of distribution is 53-93 L.<br> Metabolism: Metabolized primarily by CYP2C9 and glucuronidation.<br> Excretion: 20% excreted in urine, remainder in feces.<br> Half-Life: Terminal elimination half-life is 11-15 hours. |
| Formulations | Available as oral tablets in 75 mg, 150 mg, and 300 mg strengths. |
| Storage Conditions | Store at room temperature (68-77°F; 20-25°C), protect from moisture. |
| Safety Information | Generally well-tolerated. Side effects may include dizziness, headache, and fatigue. Use with caution in patients with renal or hepatic impairment. |
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