Isobutyl chloroformate

Isobutyl chloroformate is an organic compound with the chemical formula C₅H₉ClO₂. It consists of a chloroformate group (-OCOCl) attached to an isobutyl group (-CH₂CH(CH₃)₂). This structure makes it an ester of chloroformic acid and isobutanol, combining the properties of esters and acyl chlorides.

Isobutyl chloroformate is widely used as a reagent in organic synthesis, particularly in the production of pharmaceuticals, agrochemicals, and other fine chemicals. It is valued for its ability to introduce the chloroformate group into target molecules, which is useful in the synthesis of carbamates, carbonates, and other derivatives. It is also employed in peptide coupling reactions and the modification of biomolecules.

The compound is typically a clear, colorless to pale yellow liquid with a pungent odor. It is highly reactive, moisture-sensitive, and can cause severe irritation to the skin, eyes, and respiratory system. Proper handling, including the use of personal protective equipment (PPE) and working in a fume hood, is essential. It should be stored in a cool, dry place, away from moisture and incompatible materials.

ISOBUTYL CHLOROFORMATE: TECHNICAL DATA SHEET

Key Properties

Applications

Safety & Handling

References:

Handbook of Reagents for Organic Synthesis

NFPA 704: 3-2-1 (Health-Fire-Reactivity)

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