2-Amino-3-(1,2-dihydro-2-oxoquinoline-4-yl)propanoic acid

CAS No.: 5162-90-3 | Molecular Weight: 232.24 g/mol

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1. Chemical Identification

Property	Specification
IUPAC Name	2-Amino-3-(2-oxo-1,2-dihydroquinolin-4-yl)propanoic acid
Common Name	Rebamipide
Molecular Formula	C₁₂H₁₂N₂O₃
CAS No.	5162-90-3
Therapeutic Class	Gastric Mucosa Protective Agent

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2. Physical & Chemical Properties

Parameter	Value
Appearance	White to off-white crystalline powder
Purity (HPLC)	≥99%
Melting Point	290°C (dec.)
Density	1.343 g/cm³
Solubility	Slightly soluble in DMSO (<10 mg/mL); practically insoluble in water
Storage	2-8°C in airtight, light-resistant container

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3. Production & Supply

Parameter	Detail
Annual Capacity	200 metric tons
MOQ	100g
Packaging	100g (amber glass bottle), 1kg (double PE bag), 25kg (fiber drum)
Shelf Life	36 months

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4. Quality Standards

Test	Specification
Purity (HPLC)	≥99.0%
Related Substances	≤1.0% total
Heavy Metals	≤10 ppm
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

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5. Pharmacological Applications

Mechanism of Action:Stimulates prostaglandin E₂ synthesisIncreases gastric mucin (MUC5AC) productionScavenges hydroxyl radicalsClinical Indications:Gastric ulcer treatmentChronic gastritis managementNSAID-induced gastric injury prevention

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