Isopropyl chloroacetate

​Isopropyl Chloroacetate

Chemical Formula: C₅H₉ClO₂
Structure: Ester of ​chloroacetic acid and ​isopropanol, with:

A ​chloroacetate group (-OCOCH₂Cl).An ​isopropyl group (-CH(CH₃)₂).Combines properties of esters and alkyl halides.

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​Physical Properties

​Appearance: Clear, colorless to pale yellow liquid.​Odor: Mild ester-like odor.​Reactivity:​Moisture-sensitive: Reacts with water/humidity.Highly reactive in nucleophilic substitution and esterification reactions.

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​Applications

​Organic Synthesis:Reagent for introducing ​chloroacetyl groups into molecules.Production of ​pharmaceuticals, ​agrochemicals, and fine chemicals.​Biomolecule Modification:Functionalizes peptides and biomolecules via alkylation.

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​Safety Considerations ⚠️

​Health Hazards:Causes ​severe irritation to skin, eyes, and respiratory system.​Handling:Use ​PPE (gloves, goggles, respirator) and work in a ​fume hood.​Storage:Store in a ​cool, dry, airtight container away from ​moisture and incompatible substances (e.g., bases, oxidizers).

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Summary:
Isopropyl chloroacetate’s ​reactivity and ​chloroacetyl-transfer capability make it vital in drug synthesis and biomolecule engineering. Strict ​safety protocols are mandatory due to its corrosive and moisture-sensitive nature.

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