Ethyl bromoacetate

Ethyl Bromoacetate

Chemical Formula: C₄H₇BrO₂
Structure: Halogenated ester composed of a ​bromoacetate group (BrCH₂COO-) bonded to an ​ethyl group (-CH₂CH₃). Derived from bromoacetic acid and ethanol.

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​Physical Properties

​Appearance: Clear, colorless to pale yellow liquid.​Odor: Pungent.​Reactivity:Highly reactive in nucleophilic substitution reactions.Moisture-sensitive (hydrolyzes to release corrosive byproducts).

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​Applications

​Organic Synthesis:Reagent for introducing ​bromoacetyl groups into molecules.Used in synthesizing ​pharmaceuticals, agrochemicals, and fine chemicals.​Biomolecule Modification:Functionalizes peptides and biomolecules via bromoacetylation.​Industrial Products:Intermediate in the production of ​dyes and ​fragrances.

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​Safety Considerations ⚠️

​Health Hazards:Causes ​severe irritation to skin, eyes, and respiratory system.​Handling:Use ​PPE (gloves, goggles, lab coat) and work in a ​fume hood.​Storage:Store in a ​cool, dry place away from ​moisture and incompatible substances (e.g., bases, oxidizers).

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Summary:
Ethyl bromoacetate’s ​reactivity and ​bromoacetyl-transfer capability make it vital in drug synthesis, biomolecule engineering, and specialty chemical production. Strict ​safety protocols are mandatory due to its corrosive and moisture-sensitive nature.

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