Ethyl 2-bromo-2-methylpropionate

​Ethyl 2-Bromo-2-methylpropionate

Chemical Formula: C₆H₁₁BrO₂
Structure: Halogenated ester with:

An ​ethyl ester group (-COOCH₂CH₃).A ​2-bromo-2-methylpropionate backbone:​Bromine atom (-Br) and ​methyl group (-CH₃) bonded to the same carbon adjacent to the carbonyl group.

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​Physical Properties

​Appearance: Clear, colorless to pale yellow liquid.​Odor: Mild ester-like odor.​Reactivity:​Moisture-sensitive: Reacts with water/humidity.High reactivity in ​alkylation and ​nucleophilic substitution reactions.

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​Applications

​Organic Synthesis:Reagent for introducing ​2-bromo-2-methylpropionyl groups into molecules.Synthesis of ​pharmaceuticals (e.g., bioactive molecules) and ​agrochemicals.​Biomolecule Modification:Functionalizes peptides and proteins via alkylation.​Polymer & Specialty Chemicals:Intermediate for ​polymers (e.g., acrylic resins) and ​specialty chemicals.

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​Safety Considerations ⚠️

​Health Hazards:Causes ​severe irritation to skin, eyes, and respiratory system.​Handling:Use ​PPE (gloves, goggles, respirator) and work in a ​fume hood.​Storage:Store in a ​cool, dry, airtight container away from ​moisture and incompatible substances (e.g., strong bases, oxidizers).

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Summary:
Ethyl 2-bromo-2-methylpropionate’s ​reactive halogenated ester structure drives its use in drug discovery, agrochemicals, and polymer chemistry. Strict ​safety protocols are essential due to its irritant properties and moisture sensitivity.

Ethyl 2-Bromo-2-methylpropionate Technical Overview

1. Fundamental Chemical Properties

Property	Specification
Chemical Name	Ethyl 2-bromo-2-methylpropionate
CAS Number	600-00-0
Molecular Formula	C₆H₁₁BrO₂
Molecular Weight	195.06 g/mol
Appearance	Colorless to pale yellow liquid
Boiling Point	155-157°C
Density (25°C)	1.328 g/cm³
Refractive Index	1.438-1.442
Solubility	Soluble in most organic solvents
Flash Point	52°C (closed cup)

2. Key Applications and Reactivity

Application Area	Primary Use
Pharmaceutical Synthesis	Alkylating agent for active pharmaceutical ingredients
Polymer Chemistry	Initiator for atom transfer radical polymerization (ATRP)
Organic Synthesis	Building block for ester derivatives
Agrochemicals	Intermediate for crop protection agents

Reactivity Characteristic	Description
Electrophilic Reactivity	High at brominated carbon
Hydrolytic Stability	Stable under neutral conditions
Thermal Decomposition	>200°C
Storage Stability	12+ months at 2-8°C under inert gas

3. Safety and Handling Considerations

Safety Aspect	Requirement
Storage Conditions	Refrigerated, under nitrogen atmosphere
Personal Protection	Chemical-resistant gloves, face shield
Ventilation	Required in handling areas
Fire Fighting Measures	Alcohol-resistant foam, dry chemical
First Aid Measures	Flush eyes/skin with water if contacted

This brominated ester compound is particularly valuable in controlled polymerization processes and specialty chemical synthesis. Its α-bromoester structure makes it a versatile intermediate for carbon-carbon bond formation reactions.

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