4-Bromobenzoyl chloride

​4-Bromobenzoyl Chloride

Chemical Formula: C₇H₄BrClO
Structure: Acyl chloride derivative of ​4-bromobenzoic acid, with:

A ​bromine atom (-Br) at the ​4-position of the benzene ring.A ​carbonyl chloride group (-COCl) at the ​1-position.

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​Physical Properties

​Appearance: Clear, colorless to pale yellow liquid.​Odor: Pungent.​Reactivity:​Moisture-sensitive: Reacts violently with water, releasing HCl.Highly reactive in ​acylation reactions (e.g., Friedel-Crafts, nucleophilic substitutions).

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​Applications

​Organic Synthesis:Reagent for introducing ​4-bromobenzoyl groups into molecules.Synthesis of ​pharmaceuticals (e.g., kinase inhibitors) and ​agrochemicals.​Biomolecule Modification:Acylation of peptides/proteins for functionalization.​Industrial Chemistry:Production of ​dyes (e.g., azo dyes) and ​polymers (e.g., polyamides).

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​Safety Considerations ⚠️

​Health Hazards:​Corrosive: Causes severe burns to skin, eyes, and respiratory tract.Releases ​HCl gas upon hydrolysis.​Handling:Use ​PPE (gloves, goggles, respirator) and work in a ​fume hood.​Storage:Store in a ​cool, dry, airtight container away from ​moisture and incompatible substances (e.g., bases, alcohols).

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Summary:
4-Bromobenzoyl chloride’s ​high reactivity and ​acyl chloride functionality make it indispensable in drug discovery, agrochemicals, and polymer chemistry. Strict ​safety protocols are critical due to its corrosive nature and moisture sensitivity.

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