2-cyanoethyl N,N,N’,N’-tetraisopropyl-phosphordiamidite

2-cyanoethyl N,N,N’,N’-tetraisopropyl-phosphordiamidite – Names and Identifiers

2-cyanoethyl N,N,N’,N’-tetraisopropyl-phosphordiamidite – Physico-chemical Properties

2-cyanoethyl N,N,N’,N’-tetraisopropyl-phosphordiamidite – Risk and Safety

2-cyanoethyl N,N,N’,N’-tetraisopropyl-phosphordiamidite – Introduction

Application Bis (diisopropylamino) (2-cyanoethoxy) phosphine is an intermediate in organic synthesis and pharmaceutical research and development. It can be used to synthesize phosphite during laboratory research Reagents.
Preparation Add 15g tris (diisopropylamino) phosphine and 200ml dichloromethane to the three-mouth bottle, stir until completely dissolved, then add 3.86g of 3-hydroxypropiononitrile and 3.80g of 1H-tetrazole, and maintain the obtained solution at a temperature of -20 ° C- 0°C for reaction for 10 hours; Then, suction filtration and desalting, saturated sodium bicarbonate washing, saturated sodium chloride washing, liquid separation, sodium sulfate drying organic phase, suction filtration, the solvent is distilled under reduced pressure to obtain a white or light yellow liquid; the oil pump distilled under reduced pressure to obtain a colorless transparent liquid bis (diisopropylamino) (2-cyanoethoxy) phosphine 7g. 51.5% molar yield.
Reagents for the synthesis of phosphorite nucleotides

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