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(S)-10-Hydroxycamptothecin CAS: 19685-09-7

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CAS: 19685-09-7

Purity: ≥99%

Capacity: 200mt/year MOQ: 217g

Application: Organic Intermediate

Standard: Enterprise export

Manufacturer: Jinan Finer Chemical Co., Ltd

Synonyms: (4S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 10-Hydroxycamptothecin 10-Hydroxycamptothecine Molecular Formula: C20H16N2O5

Molecular Weight: 364.35

CAS Registry Number: 19685-09-7

Density: 1.60

Melting point: 265-270 ºC

(S)-10-Hydroxycamptothecin, with the CAS number 19685-09-7, is a naturally occurring alkaloid derived from the seeds or root bark of the Camptotheca acuminata tree. This compound has gained significant attention due to its potent inhibitory activity against topoisomerase I, an enzyme crucial for DNA replication and repair. (S)-10-Hydroxycamptothecin exists as a yellow to orange crystalline powder and is primarily used in the development of anticancer drugs. Its mechanism of action involves stabilizing the topoisomerase I-DNA covalent complex, leading to DNA damage and ultimately cell death. This compound holds promise for the treatment of various cancers, making it a valuable addition to the field of oncology.

Property CategoryDetails
Chemical Name(S)-10-Hydroxycamptothecin
CAS Number19685-09-7
Molecular FormulaC20H16N2O5
Molecular Weight364.35 g/mol
Physical Properties
– AppearanceYellow to orange crystalline powder
– Density1.6 ± 0.1 g/cm³
– Melting Point265-270 °C
– Boiling Point820.7 ± 65.0 °C at 760 mmHg
– Flash Point450.1 ± 34.3 °C
– Refractive Index1.777
Chemical Properties
– SolubilitySoluble in organic solvents
– pHN/A (typically used in pharmaceutical formulations at physiologically compatible pH)
– StabilityStable under recommended storage conditions (-20 °C)
– Functional GroupHydroxy, quinoline, pyran ring
– ApplicationAnticancer drug development, topoisomerase I inhibitor

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