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Molecular Formula: C8H9NO3
Molecular Weight: 167.162
CAS No.: 22818-40-2
It is a medical intermediate which is mainly used in the synthesis or semi-synthetic of penicillin and cephalosporin. Because of its wide application and the synthetic medicinal products can be injected and taken orally, the clinical efficacy is better than Ampicillin. Description It is a white crystal or white crystalline powder. It is slightly soluble in ethanol and water, easily soluble in acid or alkali solution to form salt.
| Name | D(-)-4-Hydroxyphenylglycine |
| Synonyms | PH Dane-acid H-D-Phg(4-OH)-OH D-p-hydroxyphenylglycine D-4-Hydroxyphenylglycine 4-HYDROXY-D-PHENYLGLYCINE 4-Hydroxy-D-Phenylglycine (R)-4-HYDROXYPHENYLGLYCINE D(-)-4-Hydroxyphenylglycine D(-)4-P-hydroxyphenylglycine D-(-)-4-Hydroxyphenylglycine (R)-2-(4-Hydroxyphenyl)glycine (2R)-2-amino-2-phenylethanamide D-(-)-2-(4-HYDROXYPHENYL)GLYCINE 2-(4-Hydroxy-phenyl)glycin D-Form (R)-(-)-2-(4-HYDROXYPHENYL)GLYCINE (2R)-amino(4-hydroxyphenyl)ethanoic acid (R)-AMINO-(4-HYDROXY-PHENYL)-ACETIC ACID (R)-(-)-AMINO(4-HYDROXYPHENYL)ACETIC ACID (R)-ALPHA-AMINO-4-HYDROXYPHENYLACETIC ACID (r)-alpha-amino-4-hydroxybenzeneacetic acid (R)-(-)-alpha-Amino-(4-hydroxyphenyl)acetic acid |
| CAS | 22818-40-2 |
| EINECS | 245-247-7 |
| InChI | InChI=1/C8H10N2O/c9-7(8(10)11)6-4-2-1-3-5-6/h1-5,7H,9H2,(H2,10,11)/t7-/m1/s1 |
| Molecular Formula | C8H9NO3 |
| Molar Mass | 167.16 |
| Density | 1.396 |
| Melting Point | 240°C (dec.)(lit.) |
| Boling Point | 295.73°C (rough estimate) |
| Specific Rotation(α) | -156 º (c=1, 1 N HCl) |
| Flash Point | 149°C |
| Water Solubility | 5 g/L (20 ºC) |
| Solubility | 5g/l |
| Vapor Presure | 0Pa at 25℃ |
| Appearance | White crystal |
| Color | Clear colorless to yellow |
| BRN | 2210998 |
| pKa | 2.15±0.10(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | -158 ° (C=1, 1mol/L |
| MDL | MFCD00004262 |
| Physical and Chemical Properties | Melting point 240°C specific optical rotation -156 ° (c = 1, 1 N HCl) water-soluble 5g/L (20°C) |
| Use | Used as pharmaceutical intermediates, mainly for semi-synthetic penicillin, amoxicillin, cephalosporins and other pharmaceutical synthesis D-p-hydroxyphenylglycine is mainly used for the preparation of D-p-hydroxyphenylglycine salt (M · K) and OH-EPCP. |
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