Tetrahydrofuran CAS No. 109-99-9

Tetrahydrofuran (THF) 

CAS No.: 109-99-9 | EC No.: 203-726-8

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1. Chemical Identification

Property	Specification
IUPAC Name	Oxolane
Molecular Formula	C₄H₈O
Molecular Weight	72.11 g/mol
Appearance	Clear colorless liquid
Density	0.887 g/mL at 20°C
Melting Point	-108°C
Boiling Point	66°C
Refractive Index	n<sup>20</sup><sub>D</sub> 1.407
Flash Point	-14°C (closed cup)
Explosive Limits	1.8-11.8 vol% in air

Synonyms:
THF, Tetramethylene oxide, Oxacyclopentane

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2. Key Applications

Industrial Solvent

Polymer Industry:
✓ PVC cement solvent
✓ Polystyrene processing
✓ Magnetic tape coatingsChemical Synthesis:
✓ Grignard reactions
✓ Pharmaceutical intermediates

Chemical Intermediate

Pesticides: Phenylbutyltin synthesisPharmaceuticals:
✓ Progesterone production
✓ Rifamycin processing

Specialty Uses

Adhesives and coatingsLaboratory reagentExtraction solvent

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3. Product Advantages

✔ Excellent Solvency – Dissolves polar/nonpolar compounds
✔ Low Viscosity – Good penetration properties
✔ High Purity Grades – For sensitive applications

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4. Physical & Chemical Properties

Solubility:Miscible with water/organic solventsGood solvent for resins and polymersStability:Forms peroxides on air exposureStable under inert atmosphere

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5. Handling & Storage

Parameter	Requirement
Storage Temp	<30°C (explosion-proof area)
Packaging	200L steel drums
Shelf Life	12 months (with stabilizer)
Special Notes	Test for peroxides regularly

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6. Safety Information

Danger!

H225: Highly flammable liquid/vaporH302+H312+H332: Harmful if swallowed/in contact skin/inhaledH319: Causes serious eye irritation

Protective Measures:

P210: Keep away from heat/sparks/open flamesP280: Wear protective gloves/eye protectionP305+P351+P338: Eye contact rinse procedure

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7. Quality Specifications

Purity: ≥99.9% (GC)Water Content: ≤0.05%Peroxide Content: ≤10 ppm

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