Pivaloyl chloride CAS No.3282-30-2

Pivaloyl Chloride (CAS No. 3282-30-2) 

1. Basic Information

Chemical Name: Pivaloyl chlorideSynonyms: Trimethylacetyl chloride; 2,2-Dimethylpropanoyl chlorideCAS Number: 3282-30-2Molecular Formula: C₅H₉ClOMolecular Weight: 120.58 g/molAppearance: Colorless to pale yellow liquidOdor: Pungent, irritating odor (similar to acetic acid)Odor Threshold: <1 ppm

2. Physical and Chemical Properties

Melting Point: -57°C (-71°F)Boiling Point: 105-106°C (221-223°F)Density: 0.979 g/cm³ at 25°CRefractive Index: 1.412 at 20°CSolubility:Reacts violently with water/alcoholsSoluble in ether, benzene, chloroformVapor Pressure: 28 mmHg at 20°CFlash Point: 12°C (54°F) – Highly Flammable

3. Chemical Structure

      CH₃       |CH₃-C-CO-Cl       |      CH₃

4. Hazards (GHS Classification)

Flammability: Highly flammable liquid and vapor (H225)Health Hazards:Causes severe skin burns (H314)Causes serious eye damage (H318)Harmful if inhaled (H332)Environmental Hazards: Toxic to aquatic life (H402)NFPA Rating: Health 3, Flammability 2, Reactivity 1

5. Storage and Handling

Storage:Store under nitrogen/argon in cool (<25°C), dry placeKeep away from moisture and oxidizersHandling:Use PTFE/Viton gloves + face shieldWork in fume hood with >100 fpm airflowGround all equipment (static hazard)

6. Applications

Pharmaceuticals: Protecting group in peptide synthesisAgrochemicals: Production of pesticidesPolymer Industry: Modifier for specialty resins

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