3-Chloropropyne

3-Chloropropyne (Propargyl Chloride, CAS No. 624-65-7) 

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1. Basic Information

IUPAC Name: 3-Chloroprop-1-yneSynonyms:Propargyl chlorideChloromethylacetyleneCAS Number: 624-65-7Molecular Formula: C₃H₃ClMolecular Weight: 74.51 g/molAppearance: Colorless to pale yellow liquidOdor: Pungent, garlic-like odor

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2. Physical and Chemical Properties

Property	Value
Boiling Point	57–59°C (135–138°F)
Density	1.03 g/cm³ (20°C)
Refractive Index	1.432 (20°C)
Flash Point	-20°C (-4°F) (closed cup)
Solubility	– Water: Slightly soluble
	– Organic solvents: Miscible with ethanol, ether, acetone
Vapor Pressure	200 mmHg at 20°C

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3. Chemical Structure

   Cl      |     CH≡C-CH₃

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4. Hazards (GHS Classification)

Flammability: Highly flammable liquid (H224)Health Hazards:Fatal if inhaled (H330)Causes severe skin burns (H314)Causes serious eye damage (H318)Environmental: Toxic to aquatic life (H411)NFPA Rating: Health 3, Flammability 3, Reactivity 2

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5. Storage and Handling

Storage:Store in explosion-proof refrigerators (<10°C) under inert gas (N₂)Keep away from heat/sparks/open flamesHandling:Use explosion-proof equipment and chemical-resistant gloves (Viton®/butyl rubber)Work in a fume hood with <25% lower explosive limit (LEL) monitoring

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6. Applications

Organic Synthesis:Alkynylation agent for C-C bond formationIntermediate for pharmaceuticals (e.g., HIV protease inhibitors)Polymer Industry:Crosslinking agent for specialty resinsAgrochemicals:Building block for fungicides

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