【 WhatsApp】
+86-21-6420 0566
| OEM | OEM Services Provided |
| Feature | Good stability |
| Classification | Paint Additives |
| Advantage | Professional, Fast Delivery, Customizable | Samples | Apply for free，Contact Export Director now ↓ |
Molecular Formula: C15H22O3
Molecular Weight: 250.3
CAS No.: 25812-30-0
| Aspect | Details |
|---|---|
| Mechanism of Action | Gemfibrozil activates peroxisome proliferator-activated receptor-alpha (PPAR-α), which upregulates lipoprotein lipase (LPL) and reduces triglyceride levels. It also inhibits peripheral lipolysis and decreases hepatic triglyceride production. Additionally, it increases HDL cholesterol levels through an unknown mechanism. |
| Indications | – Lowering elevated triglyceride levels in people at risk of pancreatitis.<br>- Reducing the risk of coronary artery disease in patients with certain types of high cholesterol.<br>- Used in combination with a proper diet to treat high cholesterol and triglyceride levels. |
| Pharmacokinetics | – Absorption: Oral administration, with peak plasma concentration reached in 1 to 2 hours.<br>- Distribution: Highly protein-bound (99%).<br>- Metabolism: Hepatically metabolized into inactive metabolites.<br>- Excretion: 70% excreted in urine, 6% in feces.<br>- Half-Life: Approximately 1.5 hours. |
| Dosage | Available as 600 mg oral tablets, taken twice daily 30 minutes before breakfast and dinner. |
| Special Precautions | – Use with caution in patients with mild to moderate renal impairment.<br>- Contraindicated in severe renal impairment, hepatic impairment, and gallbladder disease.<br>- Monitor for signs of gallstones, muscle pain (myopathy), liver damage, and blood disorders.<br>- Avoid use in breastfeeding women due to potential risks to the infant. |
| Adverse Effects | – Common: Dyspepsia, fatigue, rash, abdominal pain, nausea, vomiting, diarrhea.<br>- Serious: Gallstones, cholecystitis, myopathy, rhabdomyolysis, liver damage, blood disorders.<br>- Allergic reactions: Difficulty breathing, swelling, rash. |
| Contraindications | – Severe renal or hepatic impairment.<br>- Presence of gallstones or gallbladder disease.<br>- Hypersensitivity to gemfibrozil.<br>- Co-administration with certain drugs (e.g., simvastatin, repaglinide, dasabuvir) due to increased risk of adverse effects. |
| Storage Conditions | Store at room temperature (68°F to 77°F; 20°C to 25°C), with excursions permitted between 59°F to 86°F (15°C to 30°C). Keep in a cool, dry place. |
| Name | gemfibrozil |
| Synonyms | Gemd Lopid Gem-S Hidil Gozid Jezil Lipur Pilder Lipira Ausgem CI 719 CI-719 Brozil Clearol Bolutol Lipazil Polyxit Micolip Litarek Innogen Regulip Reducel Gemnpid Low-Lip Sinelip Tentroc Lipizyl Elmogan Fetinor Lipigem Ipolipid Fibrocit Trialmin Fibratol Gemlipid Normolip Decrelip Taborcil Lifibron Progemzal Synbrozil Gemfibril Lanaterom Hipolixan Cholespid HSDB 7735 CCRIS 318 Renabrazin gemfibrozil Gemfibrozil BRN 1881200 GEMFIBROZIL Gevilon Uno Gemfibromax Gemfibrozilo Gemfibrozilum WL-Gemfibrozil Apo-Gemfibrozil UNII-Q8X02027X3 Gemcitabine intermediates Gemfibrozilum [INN-Latin] Gemfibrozilo [INN-Spanish] 2,2-Dimethyl-5-(2,5-xylyloxy)valeric acid 2,2-DIMETHYL-5-(2,5-XYLYLOXY) VALERIC ACID 2,2-Dimethyl-5-(2,5-xylyloxy)valeriansaeure Valeric acid, 2,2-dimethyl-5-(2,5-xylyloxy)- 2,2-Dimethyl-5-(2,5-dimethylphenoxy)valeriansaeure 5-(2,5-Dimethylphenoxy)-2,2-dimethylpentanoic acid 2,2-DIMETHYL-5-[2,5-DIMETHYL-PHENOXY]PENTANOIC ACID 5-(2,5-DIMETHYL-PHENOXY)-2,2-DIMETHYL-PENTANOIC ACID Pentanoic acid, 5-(2,5-dimethylphenoxy)-2,2-dimethyl- PENTANOIC ACID, 5-(2,5-DIMETHYLPHENOXY)-2,2-DIMETHYL- 5-(2,5-DIMETHYLPHYLPHENOXY)-2,2-DIMETHYLPENTANOIC ACID 5-(2,5-Dimethylphenoxy)-2,2-dimethylpentanoic Acid, CI-719, Decrelip, Genlip, Gevilon, Lipozid, Lpur, Lopid |
| CAS | 25812-30-0 |
| EINECS | 247-280-2 |
| InChI | InChI=1/C15H22O3/c1-11-6-7-12(2)13(10-11)18-9-5-8-15(3,4)14(16)17/h6-7,10H,5,8-9H2,1-4H3,(H,16,17) |
| Molecular Formula | C15H22O3 |
| Molar Mass | 250.33 |
| Density | 1.1109 (rough estimate) |
| Melting Point | 61-63°C |
| Boling Point | 158-159 C |
| Flash Point | 141.6°C |
| Water Solubility | >0.5g/L(temperature not stated) |
| Solubility | Soluble in DMSO (50 mg/ml at 25 °C), water (<1 mg/ml at 25 °C), ethanol (50 mg/ml a |
| Vapor Presure | 6.13E-07mmHg at 25°C |
| Appearance | powder |
| Color | White to Off-White |
| Merck | 14,4388 |
| pKa | 4.75±0.45(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.5020 (estimate) |
| MDL | MFCD00079335 |
| Physical and Chemical Properties | Crystallized from hexane, melting point 61-63 ℃, boiling point 158~159 ℃/2.67Pa. Acute toxic LD50 mice, rats (mg/kg):3162,4786 oral. |
| Use | Blood Lipid regulating drug, can reduce blood cholesterol and triglyceride content |
| Risk Codes | R22 – Harmful if swallowed R63 – Possible risk of harm to the unborn child R62 – Possible risk of impaired fertility R46 – May cause heritable genetic damage R36/38 – Irritating to eyes and skin. R21 – Harmful in contact with skin |
| Safety Description | S36 – Wear suitable protective clothing. S53 – Avoid exposure – obtain special instructions before use. S36/37 – Wear suitable protective clothing and gloves. S26 – In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S25 – Avoid contact with eyes. |
| WGK Germany | 3 |
| RTECS | YV7120000 |
| HS Code | 2918992090 |
| Hazard Class | IRRITANT |
| Toxicity | LD50 in mice, rats (mg/kg): 3162, 4786 orally (Kurtz) |
Declaration: The products displayed on this website are intended exclusively for industrial applications or scientific research. They are not intended for medical, pharmaceutical, or food use. In accordance with applicable laws and regulations, purchasing organizations must hold valid qualifications and approvals.
For help with solutions customized to your business needs, contact Export Director now.
With 30+ years of experience and We firmly believe that product quality is the basis of cooperation.
Chat Now
TEl
+86-21-6420 0566
