Trifluoroacetyl Chloride CAS No. 354-32-5

Trifluoroacetyl Chloride 

CAS No.: 354-32-5 | EC No.: 206-556-2 | UN No.: 3057

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1. Chemical Identification

Property	Specification
IUPAC Name	2,2,2-Trifluoroacetyl chloride
Molecular Formula	C₂ClF₃O
Molecular Weight	132.47 g/mol
Appearance	Colorless gas
Density	1.335 g/cm³ (liquid at 20°C)
Melting Point	-146°C
Boiling Point	-27°C
Refractive Index	1.309
Flash Point	-58.1±25.9°C

Synonyms:
TFAC, Perfluoroacetyl chloride

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2. Key Applications

Agrochemical Synthesis

Fluorinated Pesticides: Key intermediate for modern crop protection agents

Pharmaceutical Manufacturing

Active Ingredients: Production of fluorinated drugsPeptide Synthesis: Protecting group reagent

Specialty Chemicals

Fluorinated organic intermediatesFine chemical production

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3. Product Advantages

✔ High Reactivity – Excellent acylating agent
✔ Fluorine Synergy – Enhances bioactivity of end products
✔ Process Efficiency – Enables clean reaction pathways

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4. Physical & Chemical Properties

Solubility:Reacts violently with water/alcoholsSoluble in inert organic solventsStability:Moisture-sensitive – store under dry inert gasCorrosive to most metals

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5. Handling & Storage

Parameter	Requirement
Storage Temp	-20°C (cylinder)
Packaging	10kg stainless steel cylinders
Special Notes	Use nickel/alloy equipment

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6. Safety Information

Danger!

H314: Causes severe skin burns and eye damageH330: Fatal if inhaledH331: Toxic if inhaled

Protective Measures:

P260: Do not breathe gasP280: Wear face shield/acid-resistant glovesP310: Immediate medical attention required

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7. Quality Specifications

Purity: ≥99% (GC)Acid Content: ≤0.1%Non-volatile Matter: ≤0.01%

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