Acethydrazide

Acethydrazide (CAS No. 1068-57-1) 

1. Basic Information

IUPAC Name: Acetic acid hydrazideSynonyms: Acetyl hydrazide; EthanohydrazideCAS Number: 1068-57-1Molecular Formula: C₂H₆N₂OMolecular Weight: 74.08 g/molAppearance: White crystalline powderOdor: Odorless

2. Physical and Chemical Properties

Property	Value
Melting Point	65–68°C (149–154°F)
Boiling Point	Decomposes before boiling
Density	1.17 g/cm³ (20°C)
Solubility	– Water: Highly soluble
	– Ethanol: Soluble
	– Ether: Insoluble
pKa	~3.5 (hydrazide proton)

3. Chemical Structure

   O    ║  CH₃-C-NH-NH₂

4. Hazards (GHS Classification)

Acute Toxicity:Oral LD₅₀ (rat): 500–1,000 mg/kg (Category 4)Skin Irritation: May cause mild irritation (H315)Environmental: Not classified

5. Storage and Handling

Storage:Tightly sealed in cool, dry placeProtect from moisture and oxidizing agentsHandling:Use nitrile gloves and safety gogglesAvoid dust formation

6. Applications

Pharmaceuticals: Intermediate for antibiotics (e.g., isoniazid derivatives)Organic Synthesis: Precursor for heterocycles (triazoles, oxadiazoles)Polymer Chemistry: Chain extender for polyurethanes

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