3-(Aminomethyl)pyridine

3-(Aminomethyl)pyridine (CAS No. 3731-52-0) 

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1. Basic Information

IUPAC Name: 3-(Aminomethyl)pyridineSynonyms:3-Picolylamine3-PyridylmethylamineCAS Number: 3731-52-0Molecular Formula: C₆H₈N₂Molecular Weight: 108.14 g/molAppearance: Colorless to pale yellow liquidOdor: Amine-like, fishy odor

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2. Physical and Chemical Properties

Property	Value
Boiling Point	210–212°C (410–414°F)
Density	1.04 g/cm³ (20°C)
Refractive Index	1.540–1.542 (20°C)
Flash Point	90°C (194°F) (closed cup)
Solubility	– Water: Miscible
	– Organic solvents: Soluble in ethanol, ether, chloroform
Vapor Pressure	0.1 mmHg at 20°C

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3. Chemical Structure

       N        ╱ ╲       ╱   ╲      C     C       \\   /        C-CH₂-NH₂

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4. Hazards (GHS Classification)

Health Hazards:Causes severe skin burns (H314)Causes serious eye damage (H318)Harmful if swallowed (H302)Environmental: Toxic to aquatic life (H411)NFPA Rating: Health 3, Flammability 1, Reactivity 0

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5. Storage and Handling

Storage:Keep in tightly sealed containers under nitrogenStore in a cool, dry, well-ventilated areaHandling:Use nitrile gloves, safety goggles, and a fume hoodAvoid contact with strong oxidizers

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6. Applications

Pharmaceuticals:Intermediate for antihistamines and antiviralsAgrochemicals:Building block for pesticidesOrganic Synthesis:Ligand for transition metal catalysts

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