2-Chloro-5-chloromethylthiazole CAS No.105827-91-6

2-Chloro-5-chloromethylthiazole 

CAS No.: 105827-91-6

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1. Chemical Identification

Property	Specification
IUPAC Name	2-Chloro-5-(chloromethyl)thiazole
Molecular Formula	C₄H₃Cl₂NS
Molecular Weight	168.04 g/mol

Synonyms:
5-Chloromethyl-2-chlorothiazole

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2. Physical Properties

Parameter	Value
Appearance	Colorless to pale yellow liquid
Boiling Point	85-87°C at 15 mmHg
Density	1.45 g/cm³ at 25°C
Refractive Index	1.572 (20°C)
Flash Point	92°C (closed cup)

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3. Chemical Properties

Reactivity:
✓ Electrophilic at chloromethyl position
✓ Nucleophilic at thiazole ring positionsStability:
✓ Moisture-sensitive
✓ Light-sensitive

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4. Applications

Agrochemical Intermediate:
✓ Key precursor for neonicotinoid insecticides
✓ Thiamethoxam synthesisPharmaceutical Building Block:
✓ Thiazole-containing drug developmentMaterial Science:
✓ Functionalized thiazole polymers

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5. Safety Information

Hazard Statements:

H314: Causes severe skin burns and eye damageH335: May cause respiratory irritationH411: Toxic to aquatic life with long-lasting effects

Protective Measures:

P280: Wear chemical-resistant gloves/face protectionP305+P351+P338: Eye contact rinse procedureP310: Immediate medical attention required

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