Clopidogrel hydrogen sulfate

Clopidogrel Hydrogen Sulfate (CAS No. 120202-66-6) 

1. Basic Information

IUPAC Name: Methyl (2S)-2-(2-chlorophenyl)-2-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)acetate hydrogen sulfateMolecular Formula: C₁₆H₁₆ClNO₂S·H₂SO₄Molecular Weight: 419.90 g/molAppearance: White to off-white crystalline powderOptical Rotation: [α]²⁰D = +55° to +56° (c=2, methanol)Polymorphs: Form I (thermodynamically stable) and Form II

2. Physicochemical Properties

Property	Specification
Melting Point	184–188°C (Form I, dec.)
Solubility	– Water: ~50 mg/mL (25°C)
	– Methanol: Freely soluble
pKa	4.5 (tertiary amine)
LogP (octanol/water)	3.0 (free base)
Hygroscopicity	Slightly hygroscopic

3. Pharmacopoeial Specifications

Test	USP/EP Standard
Assay (HPLC)	98.0–102.0%
Related Substances	≤0.5% any individual impurity
Sulfate Content	22.4–23.4%
Heavy Metals	≤20 ppm

4. Hazards (GHS Classification)

Acute Toxicity: Oral LD₅₀ >2,000 mg/kg (rat)Reproductive Toxicity: Category 2 (H361d)Environmental Impact: Not classified

5. Storage & Handling

Conditions: Tight containers, 15–30°C, protected from moistureHandling: Use PPE (gloves, mask) to avoid inhalation of dust

Disclaimer:

The above content is for reference and communication only among industry insiders, and does not guarantee its accuracy or completeness. According to relevant laws and regulations and the regulations of this website, units or individuals who purchase related items should obtain valid qualifications and qualification conditions.

Declaration: The products displayed on this website are intended exclusively for industrial applications or scientific research. They are not intended for medical, pharmaceutical, or food use. In accordance with applicable laws and regulations, purchasing organizations must hold valid qualifications and approvals.