N,O-Dimethylhydroxylamine hydrochloride CAS No.6638-79-5

N,O-Dimethylhydroxylamine Hydrochloride (CAS No. 6638-79-5) 

1. Basic Information

Chemical Name: N,O-Dimethylhydroxylamine hydrochlorideSynonyms:Weinreb amine hydrochlorideN-Methyl-O-methylhydroxylamine hydrochlorideCAS Number: 6638-79-5Molecular Formula: C₂H₈ClNOMolecular Weight: 97.54 g/molAppearance: White to off-white crystalline powderOdor: Odorless or faint amine-like odor

2. Physical and Chemical Properties

Melting Point: 108-112°C (226-234°F) (dec.)Solubility:Water: Highly solubleOrganic solvents: Soluble in methanol, ethanol; slightly soluble in acetonepH (1% solution): ~3-5 (acidic)Hygroscopicity: Absorbs moisture from air

3. Chemical Structure

   CH₃    |CH₃-N-OH · HCl    |    O

4. Hazards (GHS Classification)

Acute Toxicity: Harmful if swallowed (H302)Skin Irritation: Causes skin irritation (H315)Eye Irritation: Causes serious eye irritation (H319)Respiratory Irritation: May cause respiratory irritation (H335)NFPA Rating: Health 2, Flammability 1, Reactivity 0

5. Storage and Handling

Storage:Keep container tightly closed in a cool, dry place (<25°C)Store under inert gas (N₂/Ar) for long-term preservationHandling:Use nitrile gloves and safety gogglesHandle in a well-ventilated area or fume hood

6. Applications

Organic Synthesis:Key reagent in Weinreb ketone synthesisAmide formation from estersPharmaceutical Intermediates: Production of APIs

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